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chicken spaghetti in red casserole
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5 from 1 vote

Chicken Spaghetti

A creamy, rich Italian-inspired sauce loaded with cheese, chicken, and spaghetti! No Rotel or processed cheese.
Prep Time20 mins
Cook Time30 mins
Course: Main
Cuisine: American, Italian
Keyword: cheese sauce, chicken, spaghetti
Servings: 6
Calories: 523kcal
Author: DSTR


Cheese Sauce

  • 1/4 cup Unsalted butter
  • 1 small Onion diced
  • 2 cloves Garlic minced
  • 1/4 cup All-purpose flour
  • 1/2 tsp Dried oregano
  • 1/2 tsp Dried basil
  • 1/4 tsp Dried thyme
  • 1/2 tsp Kosher salt
  • 1/2 tsp Black pepper
  • 1 cup Chicken stock or broth
  • 1/2 cup Whole milk
  • 1/2 cup Half and half
  • 1/2 cup Pecorino Romano shredded
  • 2 cups Sharp cheddar cheese shredded, divided


  • 8 oz Spaghetti cooked
  • 2 cups Chicken cooked, diced
  • 14 oz Diced tomatoes drained
  • 1/2 cup Fresh parsley chopped


  • Preheat the oven to 375 degrees F. Grease a 9×13 or 10×5 casserole dish (ours is a 10×5).
  • Cook spaghetti according to package instructions for al dente. Drain and place in a large mixing bowl. Add the diced cooked chicken, tomatoes, and fresh parsley. Set aside.
  • In a saucepan melt the butter over medium-high heat. Add the onion and saute until tender. Add the garlic and cook for 1 minute.
  • Whisk in the flour, oregano, basil, thyme, salt, and pepper. Cook for 1 to 2 minutes.
  • Gradually whisk in the chicken broth, milk, and half and half until smooth. Cook until thick and bubbly. It should be the consistency of cream soup.
  • Remove from the heat and stir in the Pecorino Romano and 1 cup sharp cheddar cheese until melted. Season with salt and pepper to taste.
  • Pour the cheese sauce over the spaghetti ingredients and mix until combined.
  • Pour into the prepared baking dish. Sprinkle the remaining sharp cheese evenly over the top.
  • Bake for 25-30 minutes or until it’s hot and bubbling. Let rest about 10 minutes before serving.


Calories: 523kcal | Carbohydrates: 41g | Protein: 24g | Fat: 29g | Saturated Fat: 17g | Polyunsaturated Fat: 2g | Monounsaturated Fat: 8g | Trans Fat: 1g | Cholesterol: 93mg | Sodium: 628mg | Potassium: 445mg | Fiber: 3g | Sugar: 5g | Vitamin A: 1284IU | Vitamin C: 15mg | Calcium: 457mg | Iron: 3mg